Nexuses between Solumedrol and Dexamethasone in Moderate to Severe Covid Disease

Introduction: Covid 19 is a disease caused by a virus belonging to SARS Co V2 family of viruses. It primarily effects the lungs resulting in inflammation and pneumonia. Objective(s): The main objective of the study is to compare the outcomes and efficacy of solumedrol and dexamethasone in moderate to severe COVID disease. Material(s) and Method(s): This cross sectional study was conducted in Central Park Medical College and Teaching Hospital, Lahore and the duration of this study was from August 2021 to March 2022. The data was collected from 100 COVID-19 patients diagnosed with moderate to severe condition of the diseases. The data was collected through non-probability consecutive sampling technique. Result(s): The data was collected from 100 patients of moderate to severe COVID-19 condition. There were 35 patients in group I and 65 patients' group II. The mean age for dexamethasone (group II) was 55.41 +/- 10.4 years and solumedrol (group I) was 56.86 +/- 9.3 years. Conclusion(s): It is concluded that both drugs dexamethasone and solumedrol are effective in improving clinical and biochemical parameters of moderate to severe covid 19 disease. Copyright © 2022 Lahore Medical And Dental College. All rights reserved.

Outcome Comparison Between Tocilizumab and Pulse Solumedrol in Severe Covid Disease Among Resource Depleted Areas

Introduction: Pandemic coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 coronavirus has recently emerged. Objective(s): The main objective of the study is to find the outcome comparison between tocilizumab and pulse solumedrol in severe COVID disease among resource depleted areas. Material(s) and Method(s): This cross sectional study was conducted in Central Park Medical College and Teaching Hospital, Lahore and the duration of this study was from August 2021 to March 2022. The data was collected through non-probability consecutive sampling technique. The data was collected into two groups. Men and non-pregnant women over 18 years old COVID diagnosis confirmed by real time polymerase chain reaction (RT-PCR) Pao2 / FIO2 <200 Laboratory: high sensitivity C reactive protein> 5 mg / L;lactic dehydrogenase (LDH) > 245 U / l;Ferritin> 300;D-dimer> 1500;Interleukin-6> 7.0 pg / ml were included. Result(s): The data was collected from 300 patients, 150 in each group. There were 72.9% male aged 41-60 years 45.8% were female with a mean age of 55.4 +/- 10.6 years. Diabetes and hypertension was the most common comorbidity in selected patients. Tocilizumab group had more number of males (P = 0.017), with higher incidence of coronary artery disease (CAD, P = 0.008). Conclusion(s): It is concluded that Tocilizumab decreased the propensity of severe COVID-19 patients to require invasive mechanical ventilation when compared to high-dose solumedrol pulse, especially in those with severe ARDS, but this did not translate to improved 30-day survival in them. Copyright © 2022 Lahore Medical And Dental College. All rights reserved.